CLSTN2

Across TCGA patient cohorts, CLSTN2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLSTN2-associated genes across cancer lineages are eIF4E, ARID1A, and Cyclin-B1. Each is linked with CLSTN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLSTN2-to-partner and partner-to-CLSTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CLSTN2-low versus CLSTN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLSTN2→partner) and Y-score (partner→CLSTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.179	+3.598	.007	.001	3	3
UCEC	ARID1A →	-0.153	-2.459	.008	.018	3	3
UCEC	Cyclin-B1 →	+0.612	+1.777	<.001	.002	3	3
UCEC	MEK1 →	+0.484	+4.169	<.001	<.001	3	2
UCEC	PDCD4 →	-0.416	-2.000	.005	.029	3	2
UCEC	Caspase-8 →	-0.276	-2.780	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eIF4E by CLSTN2 expression — UCEC

Explore this box plot interactively →