CLSTN2

Across TCGA cell cohorts, CLSTN2 mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CLSTN2-associated genes across cancer lineages are OBP2B, H2BC1, and LRSAM1. Each is linked with CLSTN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLSTN2-to-partner and partner-to-CLSTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OBP2B grouped by CLSTN2-low versus CLSTN2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLSTN2→partner) and Y-score (partner→CLSTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OBP2B →	+0.121	+4.285	<.001	.003	3	2
SOFT_TISSUE	H2BC1 →	+0.260	+4.392	<.001	.004	3	2
LUNG_NSCLC_LUAD	LRSAM1 →	+0.498	+2.621	.003	.003	3	2
LUNG_NSCLC_LUAD	GAGE12F →	+0.815	+1.977	<.001	.005	3	2
LUNG_NSCLC_LUAD	OR4M2 →	+0.084	+2.565	.001	.002	3	2
BLOOD_Myeloma	SMYD1 →	+0.043	+4.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

OBP2B by CLSTN2 expression — BLOOD_Myeloma

Explore this box plot interactively →