CLRN3

Across TCGA patient cohorts, CLRN3 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLRN3-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and Notch1. Each is linked with CLRN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLRN3-to-partner and partner-to-CLRN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CLRN3-low versus CLRN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLRN3→partner) and Y-score (partner→CLRN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.171	-3.807	.009	<.001	3	1
UCEC	MEK1 →	+0.349	+2.000	.015	.030	3	1
UCEC	Notch1 →	+0.200	+3.598	<.001	.001	3	1
UCEC	p62 Lck ligand →	+0.261	+1.584	.041	.036	3	1
UCEC	Annexin-1 →	+0.570	+2.019	.005	.017	3	1
UCEC	ATM →	-0.424	-1.584	.017	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK_pT183_Y185 by CLRN3 expression — UCEC

Explore this box plot interactively →