CLRN2

Across TCGA patient cohorts, CLRN2 mutation is significantly associated with the immune_cell of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLRN2-associated genes across cancer lineages are Neurons, Skeletal muscle, and Osteoblast. Each is linked with CLRN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLRN2-to-partner and partner-to-CLRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neurons grouped by CLRN2-low versus CLRN2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLRN2→partner) and Y-score (partner→CLRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Neurons →	+0.018	+2.321	.007	.036	3	2
LUSC	Skeletal muscle →	+0.038	+2.321	.005	.036	3	2
STAD	Osteoblast →	+0.050	+3.669	<.001	.049	3	1
SKCM	CLP →	+0.110	+3.189	.009	.010	3	1
COAD	Adipocytes →	+0.055	+3.431	<.001	.020	3	1
UCEC	Endothelial cells →	-0.040	-2.957	.010	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Neurons by CLRN2 expression — LUSC

Explore this box plot interactively →