CLRN2

Across TCGA cell cohorts, CLRN2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLRN2-associated genes across cancer lineages are OR4A47, C6orf118, and GRM6. Each is linked with CLRN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLRN2-to-partner and partner-to-CLRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4A47 grouped by CLRN2-low versus CLRN2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLRN2→partner) and Y-score (partner→CLRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4A47 →	+0.029	+5.228	<.001	.005	3	2
LARGE_INTESTINE	C6orf118 →	+0.125	+3.793	<.001	.007	3	1
LARGE_INTESTINE	GRM6 →	+0.063	+3.793	.009	.007	3	1
LARGE_INTESTINE	RESP18 →	+0.040	+4.217	<.001	.001	3	1
LARGE_INTESTINE	SPRR4 →	+0.124	+3.930	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR4F5 →	+0.012	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR4A47 by CLRN2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →