CLRN2

Across TCGA cell cohorts, CLRN2 mutation is significantly associated with the mutation status of many other genes, with 758 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLRN2-associated genes across cancer lineages are KDM4C, ELN, and RAB40AL. Each is linked with CLRN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLRN2-to-partner and partner-to-CLRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KDM4C grouped by CLRN2-low versus CLRN2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLRN2→partner) and Y-score (partner→CLRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KDM4C →	+4.459	+5.277	.005	.005	1	3
OVARY	ELN →	+5.415	+5.415	.004	.004	1	3
OVARY	RAB40AL →	+4.415	+4.977	.007	.007	1	3
LARGE_INTESTINE	ZNF831 →	+2.159	+3.807	.007	.007	1	3
LARGE_INTESTINE	RHBDF2 →	+3.007	+3.584	.008	.008	1	3
BLOOD_Lymphoma	TTC28 →	+4.014	+4.969	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 758 associations by consensus.

KDM4C by CLRN2 expression — CNS

Explore this box plot interactively →