CLPX

Across TCGA patient cohorts, CLPX mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLPX-associated genes across cancer lineages are EGFR_pY1068, IGFBP2, and INPP4B. Each is linked with CLPX in more than 1 cancer types. Because this analysis shows association rather than direction, both CLPX-to-partner and partner-to-CLPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CLPX-low versus CLPX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPX→partner) and Y-score (partner→CLPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.249	-1.502	.006	.030	3	1
UCEC	IGFBP2 →	-0.637	-1.700	.007	.040	3	1
UCEC	INPP4B →	-0.309	-2.807	.009	.002	3	1
UCEC	Ku80 →	+0.208	+1.820	.016	.014	3	1
UCEC	MEK1 →	+0.328	+2.321	.014	.005	3	1
UCEC	p62 Lck ligand →	+0.285	+2.125	.017	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by CLPX expression — UCEC

Explore this box plot interactively →