CLPTM1L

Across TCGA patient cohorts, CLPTM1L mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLPTM1L-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and eIF4E. Each is linked with CLPTM1L in more than 1 cancer types. Because this analysis shows association rather than direction, both CLPTM1L-to-partner and partner-to-CLPTM1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CLPTM1L-low versus CLPTM1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPTM1L→partner) and Y-score (partner→CLPTM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.671	+2.926	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.282	-3.000	<.001	<.001	3	1
UCEC	eIF4E →	+0.151	+1.247	.035	.045	3	1
UCEC	ERK2 →	+0.129	+1.807	.048	.024	3	1
UCEC	Fibronectin →	-0.268	-1.896	.017	.015	3	1
UCEC	ACC1 →	+0.282	+1.598	.022	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-7-cleavedD198 by CLPTM1L expression — UCEC

Explore this box plot interactively →