CLPTM1L

Across TCGA cell cohorts, CLPTM1L mutation is significantly associated with the RNA expression of many other genes, with 237 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLPTM1L-associated genes across cancer lineages are CCDC172, LCE2A, and PLA2G3. Each is linked with CLPTM1L in more than 1 cancer types. Because this analysis shows association rather than direction, both CLPTM1L-to-partner and partner-to-CLPTM1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC172 grouped by CLPTM1L-low versus CLPTM1L-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPTM1L→partner) and Y-score (partner→CLPTM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCDC172 →	+0.046	+5.201	.005	.006	3	1
BLOOD_Leukemia	LCE2A →	+0.071	+5.969	<.001	.001	3	1
LARGE_INTESTINE	PLA2G3 →	+1.338	+3.385	<.001	.004	3	1
LARGE_INTESTINE	CBY1 →	+0.559	+3.137	.006	.007	3	1
LARGE_INTESTINE	JOSD1 →	+0.529	+3.212	.009	.006	3	1
LARGE_INTESTINE	SAMM50 →	+0.667	+3.234	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 237 associations by consensus.

CCDC172 by CLPTM1L expression — BLOOD_Leukemia

Explore this box plot interactively →