CLPTM1

Across TCGA pan-cancer cohorts, CLPTM1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CLPTM1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CLPTM1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLPTM1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, CCRCC, and UCEC are the cancer types where CLPTM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.863	1.000	.007	30	view →
CCRCC	DFS	Median	IV	0.135	0.737	.010	17	view →
UCEC	DFS	Tertile	All	0.732	0.969	.005	12	view →
PDAC	DFS	Quartile	II,III,IV	0.298	0.595	.004	10	view →
LSCC	OS	Tertile	II,III,IV	0.526	0.889	.012	8	view →
LUAD	DFS	Tertile	II,III,IV	0.138	0.693	.013	7	view →
HNSC	DFS	Quartile	All	0.793	0.580	.031	5	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CLPTM1–COAD (DFS)

Open the COAD breakdown →