CLPS

Across TCGA pan-cancer cohorts, CLPS Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CLPS data layer compared with 18 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher CLPS Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLPS expression acts as an unfavorable survival marker.

DLBC, COAD, and LUAD are the cancer types where CLPS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	II,III,IV	0.022	0.837	<.001	12	view →
COAD	OS	Median	All	0.027	0.871	<.001	12	view →
LUAD	DFS	Median	All	0.049	0.814	<.001	6	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CLPS–DLBC (DFS)

Open the DLBC breakdown →