CLPS

Across TCGA patient cohorts, CLPS protein abundance is significantly associated with the RNA expression of many other genes, with 3,419 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CLPS-associated genes across cancer lineages are NPHS1, CENPM, and RSPH6A. Each is linked with CLPS in more than 1 cancer types. Because this analysis shows association rather than direction, both CLPS-to-partner and partner-to-CLPS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLPS versus NPHS1 in PDAC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPS→partner) and Y-score (partner→CLPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NPHS1 →	+0.769	+0.862	<.001	<.001	3	2
CCRCC	CENPM →	-0.745	-1.384	.002	<.001	3	1
CCRCC	RSPH6A →	-0.154	-1.328	<.001	.001	3	1
CCRCC	SLC35F5 →	+0.477	+1.767	.003	<.001	3	1
CCRCC	GCA →	+0.404	+1.818	<.001	<.001	3	1
CCRCC	APOA1 →	+0.397	+1.579	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,419 associations by consensus.

CLPS vs NPHS1 — PDAC

Explore this scatter interactively →