CLPS

Across TCGA patient cohorts, CLPS mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLPS-associated genes across cancer lineages are TNPO3P1, MIR6771, and NAPGP2. Each is linked with CLPS in more than 1 cancer types. Because this analysis shows association rather than direction, both CLPS-to-partner and partner-to-CLPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNPO3P1 grouped by CLPS-low versus CLPS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPS→partner) and Y-score (partner→CLPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TNPO3P1 →	+0.123	+4.771	<.001	.001	3	1
UCEC	MIR6771 →	+0.675	+4.538	<.001	.006	3	1
UCEC	NAPGP2 →	+0.106	+4.267	.003	.009	3	1
UCEC	MIR5698 →	+0.858	+4.442	<.001	.007	3	1
UCEC	RN7SL612P →	+0.505	+3.993	<.001	.006	3	1
UCEC	ATP5MGP6 →	+0.617	+4.003	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

TNPO3P1 by CLPS expression — UCEC

Explore this box plot interactively →