CLPS

Across TCGA cell cohorts, CLPS RNA expression is significantly associated with the mutation status of many other genes, with 80 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CLPS-associated genes across cancer lineages are MED13, EPRS1, and ATP13A5. Each is linked with CLPS in more than 1 cancer types. Because this analysis shows association rather than direction, both CLPS-to-partner and partner-to-CLPS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED13 grouped by CLPS-low versus CLPS-high in SOFT_TISSUE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPS→partner) and Y-score (partner→CLPS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MED13 →	+4.977	+0.114	.002	<.001	3	2
SOFT_TISSUE	EPRS1 →	+4.392	+0.092	.004	<.001	3	2
SOFT_TISSUE	ATP13A5 →	+3.977	+0.076	.007	<.001	3	2
PANCREAS	UTRN →	+3.139	+0.087	.006	<.001	3	2
LUNG_SCLC	AUTS2 →	+3.169	+0.076	.005	<.001	3	2
LUNG_SCLC	ZNF226 →	+5.169	+0.083	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

MED13 by CLPS expression — SOFT_TISSUE

Explore this box plot interactively →