CLPB

Across TCGA patient cohorts, CLPB mutation is significantly associated with the RNA expression of many other genes, with 1,636 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLPB-associated genes across cancer lineages are TRIM64EP, UQCRC1, and GSR. Each is linked with CLPB in more than 2 cancer types. Because this analysis shows association rather than direction, both CLPB-to-partner and partner-to-CLPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM64EP grouped by CLPB-low versus CLPB-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPB→partner) and Y-score (partner→CLPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	TRIM64EP →	+0.068	+7.939	<.001	.008	3	3
SKCM	UQCRC1 →	+0.333	+2.018	.006	.005	3	2
SKCM	GSR →	+0.446	+2.144	.008	.009	3	2
SKCM	KCTD9 →	+0.568	+2.597	.006	.005	3	2
UCEC	TIMM44 →	+0.444	+3.627	<.001	.001	3	2
SKCM	ENO3 →	+0.642	+1.932	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,636 associations by consensus.

TRIM64EP by CLPB expression — PRAD

Explore this box plot interactively →