CLPB

Across TCGA patient cohorts, CLPB mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLPB-associated genes across cancer lineages are Fibronectin, mTOR_pS2448, and Caveolin-1. Each is linked with CLPB in more than 1 cancer types. Because this analysis shows association rather than direction, both CLPB-to-partner and partner-to-CLPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by CLPB-low versus CLPB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPB→partner) and Y-score (partner→CLPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.302	-2.449	.036	.019	3	2
UCEC	mTOR_pS2448 →	-0.132	-2.986	.042	.035	3	2
UCEC	Caveolin-1 →	-0.653	-2.321	.039	.033	3	2
SKCM	ETS-1 →	-0.262	-3.000	.029	.034	3	1
SKCM	GATA3 →	-0.277	-3.442	<.001	.004	3	1
SKCM	Transglutaminase →	-0.207	-2.321	.006	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Fibronectin by CLPB expression — UCEC

Explore this box plot interactively →