CLPB

Across TCGA cell cohorts, CLPB mutation is significantly associated with the RNA expression of many other genes, with 576 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLPB-associated genes across cancer lineages are H2BC1, KRT84, and H2AC1. Each is linked with CLPB in more than 1 cancer types. Because this analysis shows association rather than direction, both CLPB-to-partner and partner-to-CLPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by CLPB-low versus CLPB-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLPB→partner) and Y-score (partner→CLPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.216	+3.977	<.001	.007	3	1
SOFT_TISSUE	KRT84 →	+0.069	+3.930	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.096	+3.977	<.001	.007	3	1
SOFT_TISSUE	NKX6-3 →	+0.247	+3.597	<.001	.006	3	1
SOFT_TISSUE	RNASE7 →	+0.040	+3.791	.008	.007	3	1
SOFT_TISSUE	UBQLN3 →	+0.013	+3.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 576 associations by consensus.

H2BC1 by CLPB expression — SOFT_TISSUE

Explore this box plot interactively →