CLP1

Across TCGA patient cohorts, CLP1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLP1-associated genes across cancer lineages are A-Raf_pS299, MEK1, and PDCD4. Each is linked with CLP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLP1-to-partner and partner-to-CLP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CLP1-low versus CLP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLP1→partner) and Y-score (partner→CLP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.132	-3.000	.022	.036	3	1
UCEC	MEK1 →	+0.445	+3.321	.011	.010	3	1
UCEC	PDCD4 →	-0.482	-2.459	.034	.020	3	1
UCEC	Rad50 →	-0.276	-3.584	.018	.002	3	1
UCEC	Caspase-7-cleavedD198 →	+0.825	+2.341	.003	.019	3	1
UCEC	4E-BP1 →	+0.431	+3.199	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

A-Raf_pS299 by CLP1 expression — UCEC

Explore this box plot interactively →