CLP1

Across TCGA cell cohorts, CLP1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLP1-associated genes across cancer lineages are GML, TMPRSS7, and PRR30. Each is linked with CLP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLP1-to-partner and partner-to-CLP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by CLP1-low versus CLP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLP1→partner) and Y-score (partner→CLP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.088	+4.152	<.001	.009	3	1
BLOOD_Leukemia	TMPRSS7 →	+0.062	+4.276	<.001	.007	3	1
BLOOD_Leukemia	PRR30 →	+0.026	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	DPRX →	+0.117	+5.060	<.001	.001	3	1
BLOOD_Leukemia	TSSK1B →	+0.014	+4.874	<.001	.002	3	1
CNS	OOSP2 →	+0.087	+4.321	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GML by CLP1 expression — BLOOD_Leukemia

Explore this box plot interactively →