CLOCK

Across TCGA pan-cancer cohorts, CLOCK Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CLOCK data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher CLOCK Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLOCK expression acts as an unfavorable survival marker.

KICH, COAD, and SCLC are the cancer types where CLOCK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.035	0.904	<.001	30	view →
COAD	DFS	Median	II,III,IV	0.139	0.687	.001	10	view →
SCLC	DFS	Median	All	0.164	0.566	.029	6	view →
PRAD	DFS	Median	All	0.085	0.774	.007	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CLOCK–KICH (DFS)

Open the KICH breakdown →