CLOCK

Across TCGA pan-cancer cohorts, CLOCK mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CLOCK data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CLOCK mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CLOCK expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

LUAD, UCEC, and CCRCC are the cancer types where CLOCK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.659	0.884	.010	9	view →
UCEC	DFS	Tertile	All	0.968	0.784	.012	8	view →
CCRCC	DFS	Tertile	All	1.000	0.619	.033	1	view →
GBM	DFS	Quartile	All	0.552	0.841	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CLOCK–LUAD (OS)

Open the LUAD breakdown →