CLOCK

Across TCGA pan-cancer cohorts, CLOCK mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CLOCK’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where CLOCK mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CLOCK is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

PDAC, LSCC, and HNSC are the cancer types where CLOCK tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLOCK mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	−0.639	.008	2	view →
LSCC	Female	II,III,IV	+0.235	.041	2	view →
HNSC	All	IV	−0.190	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CLOCK–PDAC

Open the PDAC breakdown →