CLOCK

Across TCGA patient cohorts, CLOCK mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLOCK-associated genes across cancer lineages are EGFR_pY1068, p62 Lck ligand, and ATM. Each is linked with CLOCK in more than 1 cancer types. Because this analysis shows association rather than direction, both CLOCK-to-partner and partner-to-CLOCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CLOCK-low versus CLOCK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLOCK→partner) and Y-score (partner→CLOCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.218	-1.652	.008	.006	3	2
UCEC	p62 Lck ligand →	+0.404	+2.331	<.001	<.001	3	2
UCEC	ATM →	-0.402	-1.652	.007	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+0.485	+1.341	.013	.043	3	2
UCEC	c-Kit →	-0.173	-1.652	.024	.006	3	2
UCEC	4E-BP1 →	+0.345	+2.807	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

EGFR_pY1068 by CLOCK expression — UCEC

Explore this box plot interactively →