CLOCK

Across TCGA cell cohorts, CLOCK RNA expression is significantly associated with the go_rna of many other GO terms, with 4,478 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLOCK-associated GO terms across cancer lineages are Protein deubiquitination, Autophagosome organization, and Regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with CLOCK in more than 12 cancer types. Because this analysis shows association rather than direction, both CLOCK-to-partner and partner-to-CLOCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein deubiquitination grouped by CLOCK-low versus CLOCK-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLOCK→partner) and Y-score (partner→CLOCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Protein deubiquitination →	+0.045	+0.714	<.001	.007	3	13
OVARY	Autophagosome organization →	+0.059	+0.911	<.001	<.001	3	12
SOFT_TISSUE	Regulation of intracellular steroid hormone receptor signaling pathway →	+0.068	+0.606	<.001	<.001	3	12
LARGE_INTESTINE	Positive regulation of mRNA catabolic process →	+0.061	+0.867	<.001	<.001	3	12
URINARY_TRACT	Cellular response to environmental stimulus →	+0.058	+0.798	<.001	.004	2	13
URINARY_TRACT	Cellular response to abiotic stimulus →	+0.058	+0.798	<.001	.004	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,478 associations by consensus.

Protein deubiquitination by CLOCK expression — BLOOD_Myeloma

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