CLOCK

Across TCGA cell cohorts, CLOCK mutation is significantly associated with the RNA expression of many other genes, with 399 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLOCK-associated genes across cancer lineages are PRAMEF4, CALHM4, and SERPINA2. Each is linked with CLOCK in more than 1 cancer types. Because this analysis shows association rather than direction, both CLOCK-to-partner and partner-to-CLOCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF4 grouped by CLOCK-low versus CLOCK-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLOCK→partner) and Y-score (partner→CLOCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRAMEF4 →	+0.006	+5.285	<.001	.003	3	2
BLOOD_Leukemia	CALHM4 →	+0.038	+5.269	<.001	<.001	3	2
LUNG_SCLC	SERPINA2 →	+0.031	+5.029	<.001	.006	3	1
STOMACH	SKOR2 →	+0.023	+5.285	<.001	.003	3	1
BLOOD_Leukemia	OR10T2 →	+1.035	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+2.141	+4.551	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 399 associations by consensus.

PRAMEF4 by CLOCK expression — STOMACH

Explore this box plot interactively →