CLNS1A

Across TCGA pan-cancer cohorts, CLNS1A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CLNS1A data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CLNS1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLNS1A expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

COAD, LSCC, and OV are the cancer types where CLNS1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.846	1.000	.025	18	view →
LSCC	OS	Quartile	II,III,IV	0.926	0.575	.014	6	view →
OV	DFS	Median	All	0.843	1.000	.018	4	view →
LUAD	OS	Median	II,III,IV	1.000	0.437	.006	4	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
GBM	OS	Quartile	All	0.617	0.424	.037	2	view →
CCRCC	DFS	Quartile	III,IV	0.686	0.923	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CLNS1A–COAD (DFS)

Open the COAD breakdown →