CLNK

Across TCGA cell cohorts, CLNK RNA expression is significantly associated with the go_rna of many other GO terms, with 1,063 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CLNK-associated GO terms across cancer lineages are Positive regulation of protein deubiquitination, Neurotransmitter transport, and Positive regulation of canonical NF-kappaB signal transduction. Each is linked with CLNK in more than 4 cancer types. Because this analysis shows association rather than direction, both CLNK-to-partner and partner-to-CLNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein deubiquitination grouped by CLNK-low versus CLNK-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLNK→partner) and Y-score (partner→CLNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of protein deubiquitination →	+0.104	+0.611	<.001	.004	3	5
BLOOD_Myeloma	Neurotransmitter transport →	-0.067	-0.292	.002	.008	3	5
BLOOD_Leukemia	Positive regulation of canonical NF-kappaB signal transduction →	+0.023	+0.492	.007	.003	3	5
UPPER_AERODIGESTIVE_TRACT	Response to epidermal growth factor →	+0.096	+0.019	.005	.003	3	4
LARGE_INTESTINE	Muscle contraction →	+0.037	+0.018	.001	.008	3	4
BLOOD_Lymphoma	Antigen processing and presentation →	+0.101	+0.669	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,063 associations by consensus.

Positive regulation of protein deubiquitination by CLNK expression — BLOOD_Lymphoma

Explore this box plot interactively →