CLNK

Across TCGA cell cohorts, CLNK mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLNK-associated genes across cancer lineages are CASP12, P2RY13, and C1orf189. Each is linked with CLNK in more than 1 cancer types. Because this analysis shows association rather than direction, both CLNK-to-partner and partner-to-CLNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CASP12 grouped by CLNK-low versus CLNK-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLNK→partner) and Y-score (partner→CLNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CASP12 →	+0.011	+3.362	.007	.007	3	2
SKIN	P2RY13 →	+0.006	+4.684	<.001	.002	3	1
BLOOD_Leukemia	C1orf189 →	+0.185	+3.736	<.001	.005	3	1
BLOOD_Leukemia	MAP1LC3C →	+0.046	+3.948	<.001	.003	3	1
BLOOD_Leukemia	TSSK1B →	+0.009	+3.289	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPATA31D4 →	+0.003	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

CASP12 by CLNK expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →