CLN8

Across TCGA patient cohorts, CLN8 RNA expression is significantly associated with the mutation status of many other genes, with 11,075 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLN8-associated genes across cancer lineages are TP53, AHNAK2, and DNAH1. Each is linked with CLN8 in more than 5 cancer types. Because this analysis shows association rather than direction, both CLN8-to-partner and partner-to-CLN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by CLN8-low versus CLN8-high in BRCA.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN8→partner) and Y-score (partner→CLN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TP53 →	-0.922	-0.210	<.001	<.001	3	6
COAD	AHNAK2 →	+1.625	+0.242	.002	.001	3	4
COAD	DNAH1 →	+1.914	+0.263	.001	.001	3	3
COAD	ABCA13 →	+1.625	+0.207	.002	.004	3	3
UCEC	SEMA5A →	+1.649	+0.351	<.001	<.001	3	3
UCEC	NUP155 →	+2.080	+0.459	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,075 associations by consensus.

TP53 by CLN8 expression — BRCA

Explore this box plot interactively →