CLN8

Across TCGA patient cohorts, CLN8 mutation is significantly associated with the RNA expression of many other genes, with 935 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLN8-associated genes across cancer lineages are MIR3612, RNU6-782P, and MIR1227. Each is linked with CLN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLN8-to-partner and partner-to-CLN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3612 grouped by CLN8-low versus CLN8-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN8→partner) and Y-score (partner→CLN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR3612 →	+0.320	+7.930	<.001	.008	3	2
BLCA	RNU6-782P →	+0.455	+5.038	<.001	.009	3	2
COAD	MIR1227 →	+0.978	+3.870	<.001	.006	3	2
UCEC	CWC25 →	+0.469	+3.475	.003	.002	3	1
UCEC	ZNF280B →	+0.702	+2.711	<.001	.003	3	1
UCEC	CCL4 →	+1.132	+3.828	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 935 associations by consensus.

MIR3612 by CLN8 expression — LUAD

Explore this box plot interactively →