CLN8

Across TCGA patient cohorts, CLN8 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLN8-associated genes across cancer lineages are eEF2, A-Raf_pS299, and INPP4B. Each is linked with CLN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLN8-to-partner and partner-to-CLN8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CLN8-low versus CLN8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN8→partner) and Y-score (partner→CLN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.391	+2.321	.029	.035	3	1
UCEC	A-Raf_pS299 →	-0.244	-3.169	<.001	.018	3	1
UCEC	INPP4B →	-0.355	-2.999	.028	.035	3	1
UCEC	JNK2 →	+0.416	+2.321	<.001	.035	3	1
UCEC	MEK1 →	+0.610	+3.459	<.001	.005	3	1
UCEC	Myosin-IIa_pS1943 →	+0.309	+2.335	.002	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eEF2 by CLN8 expression — UCEC

Explore this box plot interactively →