CLN6

Across TCGA pan-cancer cohorts, CLN6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CLN6 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CLN6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLN6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

UCEC, HNSC, and GBM are the cancer types where CLN6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.775	1.000	.011	12	view →
HNSC	OS	Median	All	1.000	0.955	.027	9	view →
GBM	OS	Quartile	All	0.596	0.920	.007	5	view →
CCRCC	OS	Quartile	All	1.000	0.766	.014	4	view →
LUAD	OS	Median	All	0.949	0.981	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CLN6–UCEC (DFS)

Open the UCEC breakdown →