CLN5

Across TCGA patient cohorts, CLN5 mutation is significantly associated with the RNA expression of many other genes, with 1,733 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLN5-associated genes across cancer lineages are RNU6-1213P, CISD3, and MYO19. Each is linked with CLN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLN5-to-partner and partner-to-CLN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1213P grouped by CLN5-low versus CLN5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN5→partner) and Y-score (partner→CLN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1213P →	+0.710	+7.307	<.001	<.001	3	2
UCEC	CISD3 →	+0.494	+3.000	.009	.001	3	1
UCEC	MYO19 →	+0.557	+3.387	<.001	.004	3	1
UCEC	MAPK1 →	+0.602	+2.332	.002	.003	3	1
UCEC	SLC5A1 →	-1.328	-2.978	.002	.001	3	1
UCEC	RTCB →	+0.528	+2.375	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,733 associations by consensus.

RNU6-1213P by CLN5 expression — BLCA

Explore this box plot interactively →