CLN5

Across TCGA patient cohorts, CLN5 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLN5-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FASN. Each is linked with CLN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLN5-to-partner and partner-to-CLN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CLN5-low versus CLN5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN5→partner) and Y-score (partner→CLN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.364	-3.807	.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.176	-2.700	.001	.006	3	1
UCEC	FASN →	+0.457	+2.000	.010	.032	3	1
UCEC	FoxM1 →	+0.282	+2.000	.015	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.169	-1.986	.025	.032	3	1
UCEC	Myosin-IIa_pS1943 →	+0.307	+2.013	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

EGFR_pY1068 by CLN5 expression — UCEC

Explore this box plot interactively →