CLN5

Across TCGA cell cohorts, CLN5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,195 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CLN5-associated GO terms across cancer lineages are Endoplasmic reticulum mannose trimming, Protein deglycosylation, and Protein demannosylation. Each is linked with CLN5 in more than 17 cancer types. Because this analysis shows association rather than direction, both CLN5-to-partner and partner-to-CLN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum mannose trimming grouped by CLN5-low versus CLN5-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN5→partner) and Y-score (partner→CLN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Endoplasmic reticulum mannose trimming →	+0.124	+1.060	<.001	<.001	3	18
BONE	Protein deglycosylation →	+0.152	+1.078	<.001	.001	3	16
BREAST	Protein demannosylation →	+0.110	+0.676	<.001	<.001	3	15
BREAST	Protein alpha-1,2-demannosylation →	+0.110	+0.676	<.001	<.001	3	15
STOMACH	Retrograde transport, vesicle recycling within Golgi →	+0.113	+0.949	.004	.001	3	13
BONE	Positive regulation of translational initiation in response to stress →	+0.241	+1.191	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,195 associations by consensus.

Endoplasmic reticulum mannose trimming by CLN5 expression — STOMACH

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