Across TCGA patient cohorts, CLN3 mutation is significantly associated with the RNA expression of many other genes, with 1,289 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLN3-associated genes across cancer lineages are RORA-AS1, RNU6-1123P, and RNA5SP146. Each is linked with CLN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLN3-to-partner and partner-to-CLN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN3→partner) and Y-score (partner→CLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RORA-AS1 →	+0.289	+3.245	.004	.008	3	2
COAD	RNU6-1123P →	+0.249	+4.595	<.001	.004	3	2
UCEC	RNA5SP146 →	+0.308	+2.261	<.001	.007	3	2
COAD	REXO1L8P →	+0.030	+5.727	<.001	<.001	3	2
UCEC	ZC3H18 →	+0.457	+2.939	.002	<.001	3	2
UCEC	NDUFB8 →	+0.366	+2.906	.009	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,289 associations by consensus.

Exploration

CLN3 survival (RNA) · tumor vs normal (RNA) · all CLN3 data types