CLN3

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CLN3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLN3-associated genes across cancer lineages are Shc_pY317, Smac, and ATM. Each is linked with CLN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLN3-to-partner and partner-to-CLN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN3→partner) and Y-score (partner→CLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECShc_pY317 →-0.204-2.000.002.03232
UCECSmac →+0.237+2.000.043.03232
UCECATM →-0.573-3.156.005.01832
UCECc-Jun_pS73 →-0.141-2.000.048.03232
UCECEGFR_pY1068 →-0.381-3.807<.001<.00131
UCECJNK_pT183_Y185 →-0.205-3.169.006.01931
Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration