Across TCGA cell cohorts, CLN3 RNA expression is significantly associated with the RNA expression of many other genes, with 10,797 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible CLN3-associated genes across cancer lineages are SPNS1, PHKG2, and PPP4C. Each is linked with CLN3 in more than 17 cancer types. Because this analysis shows association rather than direction, both CLN3-to-partner and partner-to-CLN3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN3→partner) and Y-score (partner→CLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SPNS1 →	+1.021	+0.788	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	PHKG2 →	+0.780	+1.236	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	PPP4C →	+0.815	+1.301	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	CDIPT →	+1.096	+1.105	<.001	<.001	2	14
LUNG_NSCLC_LUAD	ATP6AP1 →	+1.047	+0.999	<.001	<.001	3	12
BREAST	TAOK2 →	+0.905	+1.131	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,797 associations by consensus.

Exploration

CLN3 survival (RNA) · tumor vs normal (RNA) · all CLN3 data types