Across TCGA cell cohorts, CLN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,691 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible CLN3-associated GO terms across cancer lineages are Lysosomal lumen acidification, Intracellular water homeostasis, and Vacuolar transport. Each is linked with CLN3 in more than 16 cancer types. Because this analysis shows association rather than direction, both CLN3-to-partner and partner-to-CLN3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN3→partner) and Y-score (partner→CLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Lysosomal lumen acidification →	+0.151	+0.864	<.001	<.001	3	17
LUNG_SCLC	Intracellular water homeostasis →	+0.906	+0.714	<.001	<.001	3	17
KIDNEY	Vacuolar transport →	+0.055	+0.785	<.001	.002	3	16
OVARY	Vacuolar acidification →	+0.157	+0.888	<.001	<.001	3	16
LARGE_INTESTINE	Regulation of autophagosome size →	+0.125	+1.327	<.001	<.001	3	15
BREAST	Regulation of phagosome maturation →	+0.411	+1.207	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,691 associations by consensus.

Exploration

CLN3 survival (RNA) · tumor vs normal (RNA) · all CLN3 data types