Across TCGA cell cohorts, CLN3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible CLN3-associated genes across cancer lineages are SLC17A2, LECT2, and DRD3. Each is linked with CLN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLN3-to-partner and partner-to-CLN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLN3→partner) and Y-score (partner→CLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SLC17A2 →	+0.173	+4.217	.001	.005	3	1
URINARY_TRACT	LECT2 →	+0.874	+4.217	<.001	.005	3	1
URINARY_TRACT	DRD3 →	+0.017	+4.087	<.001	.009	3	1
URINARY_TRACT	CCL11 →	+0.017	+4.087	<.001	.009	3	1
URINARY_TRACT	OR4F15 →	+0.144	+4.217	<.001	.005	3	1
URINARY_TRACT	HTR3D →	+0.032	+5.044	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

CLN3 survival (RNA) · tumor vs normal (RNA) · all CLN3 data types