CLMN

Across TCGA patient cohorts, CLMN mutation is significantly associated with the RNA expression of many other genes, with 2,438 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLMN-associated genes across cancer lineages are RN7SKP98, TRAJ46, and MED28P2. Each is linked with CLMN in more than 2 cancer types. Because this analysis shows association rather than direction, both CLMN-to-partner and partner-to-CLMN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP98 grouped by CLMN-low versus CLMN-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLMN→partner) and Y-score (partner→CLMN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP98 →	+0.526	+4.143	<.001	.004	3	3
COAD	TRAJ46 →	+0.589	+3.779	<.001	.003	3	3
LUAD	MED28P2 →	+0.068	+5.315	.003	.003	3	3
LUSC	RNA5SP418 →	+0.554	+3.393	<.001	.004	3	3
LUSC	RNA5SP413 →	+0.968	+3.496	<.001	.003	3	3
UCEC	ITGAE →	+0.539	+2.459	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,438 associations by consensus.

RN7SKP98 by CLMN expression — BLCA

Explore this box plot interactively →