CLMN

Across TCGA patient cohorts, CLMN mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLMN-associated genes across cancer lineages are p27_pT157, ASNS, and ATM. Each is linked with CLMN in more than 1 cancer types. Because this analysis shows association rather than direction, both CLMN-to-partner and partner-to-CLMN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by CLMN-low versus CLMN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLMN→partner) and Y-score (partner→CLMN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT157 →	-0.044	-1.716	.018	.003	3	2
UCEC	ASNS →	+0.301	+1.765	.010	.013	3	2
UCEC	ATM →	-0.412	-2.571	.005	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.710	+2.604	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.265	+2.459	.002	.018	3	2
UCEC	C-Raf →	+0.128	+1.584	.005	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

p27_pT157 by CLMN expression — UCEC

Explore this box plot interactively →