CLMN

Across TCGA cell cohorts, CLMN mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CLMN-associated genes across cancer lineages are OR6V1, OR4M2, and NOTO. Each is linked with CLMN in more than 2 cancer types. Because this analysis shows association rather than direction, both CLMN-to-partner and partner-to-CLMN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6V1 grouped by CLMN-low versus CLMN-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLMN→partner) and Y-score (partner→CLMN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR6V1 →	+0.069	+5.369	<.001	.004	3	3
LUNG_NSCLC_LUAD	OR4M2 →	+0.267	+4.887	<.001	.009	3	2
SKIN	NOTO →	+0.021	+5.199	<.001	<.001	3	2
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR4D6 →	+0.046	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

OR6V1 by CLMN expression — SOFT_TISSUE

Explore this box plot interactively →