CLK4

Across TCGA pan-cancer cohorts, CLK4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CLK4 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CLK4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CLK4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, GBM, and LUAD are the cancer types where CLK4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	1.000	0.697	.035	3	view →
GBM	DFS	Quartile	All	0.186	0.391	.031	2	view →
LUAD	OS	Median	II,III,IV	0.359	1.000	.024	2	view →
LSCC	DFS	Median	II,III,IV	1.000	0.451	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CLK4–HNSC (OS)

Open the HNSC breakdown →