CLK4

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CLK4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,716 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CLK4-associated genes across cancer lineages are PTGES2, RNVU1-34, and MIR3189. Each is linked with CLK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLK4-to-partner and partner-to-CLK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLK4 versus PTGES2 in HNSC, with a Pearson correlation of -0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK4→partner) and Y-score (partner→CLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCPTGES2 →-1.027-0.629.009<.00132
HNSCRNVU1-34 →-2.747-0.951<.001<.00132
LUADMIR3189 →-1.593-0.321.007.00932
LUADSRD5A1 →+0.693+0.411.003.00432
LUADPTPRN2 →-1.052-0.433.001.00132
CCRCCTMTC2 →-0.826-0.550.003<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,716 associations by consensus.

CLK4 vs PTGES2 — HNSC

Per-sample scatter of CLK4 vs PTGES2 in HNSC (Pearson r = -0.54).

Explore this scatter interactively →

Exploration