CLK4

Across TCGA patient cohorts, CLK4 mutation is significantly associated with the RNA expression of many other genes, with 3,627 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLK4-associated genes across cancer lineages are H3Y1, SNRPBP1, and GPR6. Each is linked with CLK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLK4-to-partner and partner-to-CLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3Y1 grouped by CLK4-low versus CLK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK4→partner) and Y-score (partner→CLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H3Y1 →	+0.617	+1.521	<.001	.006	3	3
SKCM	SNRPBP1 →	+0.169	+4.324	.001	.007	3	3
READ	GPR6 →	+0.055	+5.039	<.001	.008	3	2
CESC	LINC02500 →	+0.657	+4.144	<.001	.009	3	2
UCEC	RNA5SP410 →	+0.471	+1.863	<.001	.001	3	2
UCEC	RNA5SP413 →	+1.064	+1.774	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,627 associations by consensus.

H3Y1 by CLK4 expression — UCEC

Explore this box plot interactively →