CLK4

Across TCGA cell cohorts, CLK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,612 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CLK4-associated GO terms across cancer lineages are Target-directed miRNA degradation, Regulation of mRNA splicing, via spliceosome, and Sperm motility. Each is linked with CLK4 in more than 16 cancer types. Because this analysis shows association rather than direction, both CLK4-to-partner and partner-to-CLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Target-directed miRNA degradation grouped by CLK4-low versus CLK4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK4→partner) and Y-score (partner→CLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Target-directed miRNA degradation →	+0.131	+0.918	<.001	<.001	3	17
OESOPHAGUS	Regulation of mRNA splicing, via spliceosome →	+0.102	+1.337	.004	.003	3	16
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.169	-1.732	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.169	-1.732	<.001	<.001	3	15
LARGE_INTESTINE	Microtubule nucleation →	+0.143	+1.179	<.001	<.001	3	15
OESOPHAGUS	mRNA splice site recognition →	+0.120	+1.031	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,612 associations by consensus.

Target-directed miRNA degradation by CLK4 expression — LUNG_SCLC

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