CLK4

Across TCGA cell cohorts, CLK4 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLK4-associated genes across cancer lineages are MYF6, IFNA8, and KRTAP10-1. Each is linked with CLK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLK4-to-partner and partner-to-CLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF6 grouped by CLK4-low versus CLK4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK4→partner) and Y-score (partner→CLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MYF6 →	+0.018	+4.977	.001	.007	3	1
SKIN	IFNA8 →	+0.021	+4.977	.001	.007	3	1
SKIN	KRTAP10-1 →	+0.019	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR13C3 →	+0.018	+4.887	<.001	.009	3	1
LARGE_INTESTINE	CST8 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	VCX2 →	+1.507	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MYF6 by CLK4 expression — SKIN

Explore this box plot interactively →