CLK3

Across TCGA patient cohorts, CLK3 protein abundance is significantly associated with the RNA expression of many other genes, with 4,153 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible CLK3-associated genes across cancer lineages are SEPSECS-AS1, TMEM8B, and SALL2. Each is linked with CLK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLK3-to-partner and partner-to-CLK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLK3 versus SEPSECS-AS1 in UCEC, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK3→partner) and Y-score (partner→CLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEPSECS-AS1 →	-0.683	-0.190	<.001	.005	3	3
BRCA	TMEM8B →	-0.488	-0.220	.006	.006	3	3
LUAD	SALL2 →	-0.917	-0.234	<.001	<.001	3	3
HNSC	GJB3 →	+0.939	+0.295	.005	<.001	3	3
LUAD	LINC02323 →	+0.759	+0.221	<.001	.001	3	3
OV	PPCDC →	+0.422	+0.287	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,153 associations by consensus.

CLK3 vs SEPSECS-AS1 — UCEC

Explore this scatter interactively →