CLK3

Across TCGA patient cohorts, CLK3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLK3-associated genes across cancer lineages are PARP_cleaved, 14-3-3_beta, and EGFR_pY1068. Each is linked with CLK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLK3-to-partner and partner-to-CLK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PARP_cleaved grouped by CLK3-low versus CLK3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLK3→partner) and Y-score (partner→CLK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PARP_cleaved →	+0.618	+2.832	.035	.035	3	1
UCEC	14-3-3_beta →	-0.088	-1.847	.029	.049	3	1
UCEC	EGFR_pY1068 →	-0.261	-1.874	.009	.049	3	1
UCEC	EGFR →	-0.176	-3.000	.006	.036	3	1
UCEC	A-Raf_pS299 →	-0.126	-1.906	.008	.016	3	1
UCEC	Notch1 →	+0.187	+1.887	<.001	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PARP_cleaved by CLK3 expression — COAD

Explore this box plot interactively →